N. Gasparyan, G. Gevorgyan, R. Paronikyan
Jul 1, 2005
Citations
0
Influential Citations
4
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
A series of 1-(4-substituted phenyl)-1-alkyl-2-phenyl-3-morpholinopropanols (I) have been synthesized via the interaction of 4-substituted α-phenyl-β-morpholinopropiophenones with Grignard's reagents in ether. The antiinflammatory and analgesic (non-narcotic) properties of the synthesized compounds have been evaluated. The most pronounced analgesic (non-narcotic) activity was observed for aminopropanols with 1-isoalkyl (isopropyl, isobutyl, isoamyl) radicals.