P. Mhaske, S. H. Shelke, H. Raundal
Feb 20, 2014
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Journal
Journal of The Korean Chemical Society
Abstract
Department of Chemistry, HPT Arts and RYK Science College, Nashik India-422 005(Received September 2, 2013; Accepted December 17, 2013)ABSTRACT. In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanonederivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazi ne byusing 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All thenewly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro anti-bacterial activity. Most of the compounds show moderate to good antimicrobial activity.Key words: Thiazole, Piperazine, EDCl-HOBt, Antimicrobial activity