Ying-Hua Wu, J. Hong
Nov 1, 2005
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Journal
Archiv der Pharmazie
Abstract
Novel acyclic Neplanocin A analogues were designed and synthesized. The coupling of the alkyl bromide 6 with nucleosidic bases (T, U, 5‐FU, 5‐IU, C, A) and desilylation afforded a series of novel acyclic nucleosides. The synthesized compounds 13–18 were evaluated for their antiviral and antitumor activity.