Qingyun Ren, Yanxia Shi, Yucheng Gu
Mar 1, 2014
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0
Influential Citations
2
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Journal
Journal of Heterocyclic Chemistry
Abstract
Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidin-4(3H)-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reactions with the corresponding iminophosphoranes 4, aryl isocyanate, and amines in good yields. Their structures were clearly verified by IR spectroscopy, 1H-NMR spectroscopy, EI-MS, and elemental analysis, and in the case of compound 6i, further analyzed by single-crystal X-ray diffraction. The preliminary results of an in vivo bioassay showed that some compounds display moderate antifungal activity.