Joga Sree, Ram Babu, K. Sudhakar Babu
Sep 2, 2016
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
International Journal of Pharma Research & Review
Abstract
During the course of our investigation in the field of carboxylic acid antithrombotic agents, we have identified and synthesized 2-((2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)methyl)-4-methylthiazole-5-carboxylicacid derivatives (5a-k), with good in vivo activity. These findings prompted us to prepare new 2-((2-chlorophenyl)(6,7-dihydrothieno [3,2-c]pyridin-5(4H)-yl)methyl)-4-methylthiazole-5-carboxylic acid derivatives (5a-k),were synthesized by reaction of 2-((2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)methyl)-4-methylthiazole-5-carboxylic acid with substituted halo anilines by using thionyl chloride and hydroxy benzotriazole in presence of triethylamine in Dichloromethane obtained the tile compounds. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.