Tayfun Arslan, Gonca Çelik, Habip Çelik
Sep 1, 2016
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Influential Citations
32
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Quality indicators
Journal
Archiv der Pharmazie
Abstract
Design and synthesis of a new type of bischalcones as an alternative to natural and synthetic bischalcones are reported for the first time. Key steps involved the solvent‐free Claisen–Schmidt condensation of chalcones, and the successful first application of the diazotization–diazocoupling reaction in the synthesis of CNNC‐linked bischalcones by simple structural modification of p‐aminoacetophenone. The structures of all compounds were confirmed by means of FT‐IR, 1H and 13C NMR, ESI/MS, and elemental analysis. In addition, the newly synthesized compounds were screened for carbonic anhydrase inhibition activities. Almost all bischalcones exhibited moderate‐to‐good inhibitory activities.