Song Yun-lon
2014
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Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
A novel insulin sensitizer,5-[(2,4-dioxothiazolidin-5-yl) methyl]-2-methoxy-N-[(3,5,6-trimethyl-pyrazin-2-yl)methyl]benzamide( Ⅰ),was designed and synthesized by combining the fragment of tetramethylpyrazine with pharmacophore of TZDs. The structure was characterized by1 H NMR and MS. Ⅰ showed approximately equal PPAR-γ agonist activity to Pioglitazone at 1. 0 ×10- 5mol·L- 1in vitro. Ⅰ could protect the vascular endothelial cells and it can be expected that the cardiovascular side effects may be reduced.