C. Ong, J. Hwang, J. Chern
Jun 1, 1988
Citations
0
Influential Citations
1
Citations
Journal
Journal of Medical Sciences
Abstract
(Z,Z) and (E,E)-3,6-Bis(2,5-dimethoxybenzylidene)-2,5-dioxopiperazine have been obtained directly from the condensation of glycin anhydride and 2,5-dimethoxybenzaldehyde. Of the two geometrical isomer, only the (E, E) isomer was found to possess both antimicrobial and potent cytotoxic activity. Reduction of the benzylidene double bond in the (E,E) isomer totally diminishes its biological activity. These results illustrate the importance of molecular configuration for the expression of biological activity.