J. Modha, J. Parmar, N. Datta
Dec 1, 2002
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0
Influential Citations
1
Citations
Journal
ChemInform
Abstract
Reaction between 6-(4'-chlorophenyl)-5-cyano-2-mercapto-3,4-dihydropyrimidin-4-onel and methyl iodide in presence of K 2 CO 3 in DMF yields the 6-(4'-chlorophenyl)-5-cyano-3-N-methyl-2-methylthio-3,4-dihydropyrimidin-4-one2, which on treatment with hydrazine hydrate affords the 6-(4'-chlorophenyl)-5-cyano-2-hydrazino-3-N-methyl-3,4-dihydropyrimidin-4-one 3. The 6-(4'-chlorophenyl)-5-cyano-3-N-methyl-2-substituted benzalhydrazino-3,4-dihydropyrimidin-4-ones 4 are synthesised by the condensation of 3 with different aryl aldehydes. Compound 4 on condensation with chloroacetyl chloride and thiolactic acid affords the corresponding 2-(4"-aryl-3"-chloro-2"-azetidinon-1"-yl-amino)-6-(4'-chlorophenyl)-5-cyano-3-N-methyl-3, 4-dihydropyrimidin 4-ones 5a-1 and 2-(2"-aryl-5"-methyl-4"-thiazolidinon-3"-yl-amino)-6-(4'-chlorophenyl)-5-cyano-3-N-methyl-3,4-dihydro-pyrimidin-4-ones 6a-1. All the products have been evaluated for their in vitro antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37 Rv.