A. B. Chidrawar
Dec 31, 2016
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Journal
International journal of scientific research
Abstract
A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti-inflammatory and anti-bacterial activity. The starting product is 6-substituted-1,3-benzothiazol-2-amine was prepared from 4-substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl-2-amines were reacted with chloroacetyl chloride to yield 2-chloro acetyl amino-6-substitued benzothiazoles, which were reacted with 2-mercaptobenzothiazole and 2-hydrazinobenzothiazole gave 2-(1,3-benzothiazol-2-yl thio)- N -(6-substitued-1,3-benzothiazol-2-yl)acetamides and 2-[2-(1,3-benzothiazol-2-yl)hydrazino]- N -(6-methyl-1,3-benzothiazol-2-yl)acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data.