T. Kano, Osamu Tokuda, K. Maruoka
Oct 16, 2006
Citations
0
Influential Citations
49
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A biphenyl-based axially chiral amino acid ( S )- 2 has been designed and synthesized. The new amino acid ( S )- 2 has been found to be a more efficient catalyst than ( S )- 1 in the direct asymmetric aldol reaction of acetone with aldehydes. For instance, the use of only 0.1 mol % of ( S )- 2 was sufficient to complete the reaction between acetone and 4-nitrobenzaldehyde, giving the corresponding aldol adduct in good yield with an excellent enantioselectivity.