G. Bish, P. D. D. Koning, Stephané P. A. Dubant
Jul 21, 2010
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Journal
Organic Process Research & Development
Abstract
A practical and scalable process for the preparation of (1s,4s)-4-(methylamino)-1′H-spiro[cyclohexane-1,3′-furo[3,4-c]pyridin]-1′-one 2a, a highly functionalized and potentially useful building block for pharmaceutical research is described. The material is prepared via an efficient two-step sequence from readily available materials and is isolated as a single diastereomer in high chemical purity.