J. Grosso, D. Nichols, M. Nichols
Nov 1, 1980
Citations
0
Influential Citations
26
Citations
Journal
Journal of medicinal chemistry
Abstract
Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.