S. Rao, R. Dubey, G. Nagarajuna
Feb 6, 2018
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Journal
Journal of The Chinese Chemical Society
Abstract
Developed a new process for gem di-chlorination of 1-(4-iodophenyl) piperidin-2-one with Thionyl chloride to synthesis Apixaban one of the intermediate, Amidation of Ethyl 4,5,6, 7-tetrahydro-1-(4-methoxy phenyl)-7-oxo-6-(4-(2oxopiperidin-1-yl) phenyl)-1H-pyrazolo [3,4-c] pyridine-3-carboxylate was developed in Sodium methoxide, formamide in Toluene as solvent and Apixaban purification was established in 20% Methanol in Acetonitrile to obtain good yield and targeted quality.