An Li-li
2006
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Influential Citations
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Quality indicators
Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesize N-[3',3'-di(phosphonoxy)propyl]3-{4-[bis(2-chloroethyl)amino]phenyl}-3-aminopropionamide and test its bone targeting characters in vitro.METHODS 3,3-di(phosphonoxy)propyl-amino(1) with hydrogenation was conjugated with N-benzyloxcarbonyl Betamerphalan(2),followed by catalytic hydrogenation for intermediate(4).Then the title conjugate T was obtained via dealkylation of phospho rate(4) by using trimethysilyl bromide.RESULTS and CONCLUSION The structure of title conjugate T was verified by()~1HNMR,IR and MS.It showed good bone-seeking ability via hydroxyapatite adhesion tests in vitro.