L. Keliang
2005
Citations
0
Influential Citations
3
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To study on the synthesis of bosentan,an endothelin receptor antagonist. Methods Starting from guaiacol and dl-diethyl-2-bromomalonate,bosentan was obtained via seven steps,substitution,cyclization,chlorination,condensation,etherification,deprotection,and saponification,etc. Results and conclusion The total yield is 15.2%.The structure is established by ~1H-NMR and MS.