Consol Bozzo, M. Pujol, X. Solans
2003
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Journal
Tetrahedron
Abstract
The 1,4-benzodioxin-2-carboxylic esters or carboxamides react with nucleophilic amines to give access to 3-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxamides and 3-aminomethyn-1,4-benzodioxin-2(3H)-one precursors of potential therapeutical compounds. The basic environment (K 2 CO 3 or amine) facilitates the process.