Mao Xue-gong
2008
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Journal
The Chinese Pharmaceutical Journal
Abstract
OBJECTIVE To study the synthetic process for bretazenil. METHODS Bretazenil was synthesized from 3-bromoaniline by cyclization, oxidation and ring-enlargement reaction, etc.RESULTS The purity of the product was above 99%. The structure of bretazenil was verified by 1H-NMR. The overall yield was 12.4%, which was higher than reported yield(4.8%). CONCLUSION It is proved to be a method with mild condition, high quality and good yield.