Marcellino Rudyanto, J. Ekowati, T. Widiandani
2014
Citations
0
Influential Citations
12
Citations
Journal
International Journal of Pharmacy and Pharmaceutical Sciences
Abstract
The specific objective of this research is to synthesize novel 1,3-benzoxazine and aminomethyl compounds from eugenol and study their biological activity. Eugenol was reacted with formaldehyde and primary amines following Mannich reactions. The obtained 1,3-benzoxazine compounds were then hydrolyzed to give the aminomethyl derivatives. All the obtained 1,3-benzoxazine and aminomethyl compounds were tested for biological activity using brine shrimp lethality test (BST). It was found that 6-allyl-8-methoxy-3-phenyl-3,4-dihydro-2H-benzo[ e][1,3]oxazine, 6-allyl-3-benzyl8-methoxy-3,4-dihydro-2H-benzo[ e][1,3]oxazine,4-allyl-2-methoxy-6-phenylaminomethylphenol, 4-allyl-2-(benzylaminomethyl)-6-methoxyphenol, and 4-allyl-2-{[(furan-2-ylmethyl)-amino]-methyl}-6-methoxyphenol show toxicity on BST, and therefore potential to be further studied for their bioactivity.