M. I. Al-Hassan
Feb 24, 1987
Citations
0
Influential Citations
9
Citations
Journal
Journal of Organometallic Chemistry
Abstract
Abstract The synthesis of broparestrol, a biologically active tetrasubstituted olefin used in dermatology, was achieved via palladium-catalyzed cross-coupling to form a CC bond followed by bromination. Broparestrol (a cis-trans mixture of α-bromo-α,β-diphenyl-β-( p -ethylphenyl)ethylene) ( 1 ) is an estrogen, used in dermatology [1,2]. In this paper we report two advantageous methods of synthesizing broparestrol involving palladium-catalyzed cross-coupling.