J. Dekeyser, C. Decock, J. Poupaert
Aug 1, 1989
Citations
0
Influential Citations
10
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Isobutyl [3-14C] cyanoacrylate and diethyl [3-14C] methylidenemalonate were synthesized by the intermediate of their protective Diels-Alder adduct with anthracene. These adducts (2a-b) were obtained in a one-pot procedure by Knoevenagel condensation of [14C] paraformaldehyde with isobutyl cyanoacetate and diethyl malonate respectively in the presence of a basic catalyst and anthracene. The adducts are stable crystalline compounds easily purified by recrystallization. The olefinic target coumpounds (1a-b) were obtained in high chemical and radiochemical purity (>99%) by thermolysis at 220 °C in mineral oil in the presence of maleic anhydride.