Panawan Moosophon, Morwenna C. Baird, S. Kanokmedhakul
Jun 1, 2010
Citations
0
Influential Citations
30
Citations
Journal
European Journal of Organic Chemistry
Abstract
The total synthesis of calystegine B 4 was achieved in 10 steps from (―)-D-lyxose by using a new synthetic strategy to obtain the requisite protected hydroxylacted 4-aminocyclohept-2-en-1-one without the problem of regioisomer formation that was a problem in the earlier synthesis of this natural product. The key steps included a Petasis―borono-Mannich reaction and a ring-closing metathesis reaction.