Zhang We
2014
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Journal
Chemical Reagents
Abstract
The capecitabine intermediate 5'-deoxy-5-fluorocytidine was synthesized from 5-fluorocytidine via selective bromination by PPh3/Br2at 5' position and hydrogenation by Pd/C within two steps and 52% yield. This method takes advantages of available materials,short reaction steps,pure configuration and excellent yield,providing new avenue of synthesizing 5'-deoxy-5-fluorocytidine and its derivatives,indicating potential application prospect.