Kun Zhang, Hongjin Xu, Zi‐Ping Liu
2019
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Journal
Chinese Journal of Organic Chemistry
Abstract
Murrayaquinone A is a carbazolequinone alkaloid isolated from the root bark of Murraya euchrestifolia Hayata. It has been found to exhibit cardiotonic activity on heart muscle. Starting from the commercially available 3-acylindole, the total synthesis of Murrayaquinone A was realized in eight steps in an overall yield of 8%. The key step of our synthesis involves a palladium-catalyzed intramolecular α-C—H alkenylation of indole derivative to construct the carbazole A ring.