Li Zhen-hua
2008
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Carbidopa was synthesized from L-α-(3,4-dimethoxybenzyl)-α-aminopropionitrile hydrochloride via hydrolysis with concentrated hydrochloric acid and condensation with urea in the presence of base to afford the key intermediate L-α-(3,4-dimethoxybenzyl)-α-ureidopropanoic acid,which was subjected to Hofmann rearrangement and then deprotection by 48% hydrobromic acid with an overall yield of about 25%.