H. Ravert, W. B. Mathews, J. Musachio
Apr 1, 1995
Citations
0
Influential Citations
6
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
[ 11 C]-Methylchloroformate, a novel [ 11 C]-acylating agent, was generated in situ from [ 11 C]-methanol and phosgene. To explore the utility of [ 11 C]-methylchloroformate, this agent was reacted with several amines to yield their corresponding [ 11 C] -labeled methylcarbamates. The average synthesis (including purification and formulation) required approximately 23 minutes from end of bombardment. The average specific activity was calculated to be approx. 607 mCi/μmole at end of synthesis with an average radiochemical yield of 6%, decay corrected to starting [ 11 C]-methanol. Preliminary results reveal that [ 11 C]-methylchloroformate is a useful general reagent for the preparation of [ 11 C]-methyl carbamates of both primary and secondary amines