P. Fabio, E. LanzilottiAnthony, S. Lang
Oct 1, 1978
Citations
0
Influential Citations
6
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A potent antiparasitic agent 3-nitro-6-propoxyimidazo[1, 2-b]-pyridazine (3) was synthesized, labeled with carbon-14 in the propoxy side chain, from n-propanol-1-14C and 6-chloro-3-nitroimidazo-[1, 2-b]pyridazine (2). The final product was obtained in 58% radiochemical yield with specific activity of 1.13 mCi/mmole and radiochemical purity of greater than 99%. The deuterium labeled compound (4) was also synthesized for absorption and metabolism studies.