A. J. Schuster, E. R. Wagner
Mar 1, 1993
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Influential Citations
4
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Carbon-14 labeled vigabatrin was synthesized in 5 steps from 5-hydroxymethyl-2-pyrrolidone tosylate and NaCN-[14C]. A key step involved reduction of the resulting nitrile in the presence of excess dimethylamine to give the dimethylamino-ethyl 2-pyrrolidone derivative in one step. This afforded an overall radiochemical yield of 22% and radiochemical purity greater than 98%.