Tobias Persson, S. K. Johansen, L. Martiny
Sep 1, 2004
Citations
0
Influential Citations
7
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The potent quorum sensing inhibitor (5Z)-4-bromo-5-(bromomethylene)-2(5H)-[2-14C]furanone has been prepared in five steps in 7.7% overall yield starting from bromo[1-14C]acetic acid. Condensation of ethyl bromo[1-14C]acetate with ethyl acetoacetate followed by decarboxylation was accelerated by microwave heating to afford [1-14C]levulinic acid. Subsequently, bromination and oxidation gave the targeted furan-2-one with a radiochemical purity of > 97% and a specific activity of 57 mCi/mmol. Copyright © 2004 John Wiley & Sons, Ltd.