G. Mokrov, A. M. Likhosherstov, V. V. Barchukov
Dec 1, 2019
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.