Zhong Wei-hui
2013
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Zhejiang Chemical Industry
Abstract
Using triphenylmethyl instead of acetyl to protect hydroxyl group in ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate,so the condensation of Cefdinir active ester with 7-amino-3-vinyl-3-cephem-4-carboxylic acid(7-AVCA) and the deprotection of hydroxyl group could be preceded successively.Green solvent 2-methyltetrahydrofuran(2-MeTHF) instead of dichloromethane was used for the preparation of Cefdinir.The recyclization and reuse of the side product triphenylphosphine oxide and 2-mercaptobenzothiazole were investigated.The present method can reduce dramatically the amount of wastes,so it can be considered of good prospect for industrial application.