L. Jian
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Cefonicid sodium was synthesized from 7-ACA by protection with hexamethyldisilazane, substitution with trimethylsilyliodide,reaction with 1-sulfomethyltetrazole-5-thiol sodium salt and then deprotection to give (6R,7R)-7-amino-3-[[(1-(sulfomethyl-1H-tetrazol-5-yl)thio]methyl]-3-cephalosporanic acid,which was subjected to condensation with dichloroacetylmandeloyl chloride with an overall yield of 62%(based on 7-ACA).