Jiang Huan-feng
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Ceftizoxime alapivoxil monohydrochloride was synthesized from (6R,7R)-7-amino-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid and 2-mercaptobenzothiazolyl (Z)-2-[[[(S)-2-(t-butoxycarbonyl)amino- 1-oxopropyl]amine]thiazol-4-yl]-2-methoxyiminoacetate by condensation, esterifi cation with iodomethyl pivalate, de- protection and then salt formation with an overall yield of 72%.