Zou Yong
2001
Citations
0
Influential Citations
2
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
The condensation of 4' methylacetophenone with ethyl trifluoroacetate by means of Na in methanol gives 1 (4 methylphenyl) 4,4,4 trifluorobutane 1,3 dione, which is cyclized with (4 sulfamoylphenyl) hydrazine hydrochloride to give celecoxib in overall yield of 48.3%.