Zhao Li-hua
2008
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Celiprolol hydrochloride was synthesized in ionic liquid [bmim]BF4 from N'-(3-acetyl-4-hydroxyphenyl)-N,N-diethylurea by reaction with epichlorohydrin to give N'-[3-acetyl-4-(2,3-epoxypropoxy)phenyl]-N,N-diethylurea, which was subjected to reaction with t-BuNH2 and then salt formation with an overall yield of about 63%.