Y. Imanishi, S. Kimura, Yoshihiro Ito
1995
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Abstract
A sequential polypeptide containing a core peptide of cell-adhesion proteins, poly-(Arg-Gly-Asp-Ser-Pro), was synthesized. The monomeric peptide Arg-Gly-Asp-Ser-Pro had a regular secondary structure, which seemed to be β-turn. On the other hand, the polypeptide did not have a regular structure. The polypeptide inhibited cell adhesion and spreading on fibronectin-coated dish, to nearly the same extent as the monomeric peptide.