Yuting Ge, S. Isoe
Jan 5, 1992
Citations
0
Influential Citations
9
Citations
Journal
Chemistry Letters
Abstract
Cerbinal (1) 1) isolated from either Cerbera manghas L. or Gardenia jasminoides Ellis, has been recognized by its characteristic Δ3,5,7,9-tetraene aromatic 10 π-system. This unusual iridoid structure is also found in baldrinal (2) 2) and viburtinal (3) 3) . Compound 3 has been traditionally used as a spasmolytic, while 2 was recently found to exhibit potent cytotoxicity against HTC hepatoma cells and anti-tumor activities against KREBS II ascitic tumor 2) . Those biological activities as well as an unusual iridoid structure made us investigate a synthetic scheme toward 1, a key compound for other natural and unnatural iridoid 10 π-systems