Paula N. Kelly, Adeline Prêtre, Siobhan Devoy
Feb 15, 2007
Citations
0
Influential Citations
50
Citations
Journal
Journal of Organometallic Chemistry
Abstract
A series of N -(ferrocenylmethyl)benzene-carboxamide derivatives ( 4a – f ) have been synthesised by coupling ferrocenylmethyl amine 3 with benzoic acid and various substituted fluorobenzoic acids using the standard 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. All compounds were fully characterised using a combination of 1 H NMR, 13 C NMR, 19 F NMR, DEPT-135, 1 H– 1 H COSY and 1 H– 13 C COSY (HMQC) spectroscopy and electrospray ionisation mass spectrometry (ESI-MS). The compounds 4a , 4d , 4e and 4f exhibited cytotoxic effects on the MDA-MB-435-S-F breast cancer cell line. Single crystal X-ray crystallographic data for 4d is also presented.