Nur Illane Mohamad Halim, K. Kassim, A. H. Fadzil
2012
Citations
0
Influential Citations
13
Citations
Journal
APCBEE Procedia
Abstract
Abstract A series of bisthiourea ligands, namely 1,2-bis(N’-2-methoxybenzoylthioureido)-4-nitrobenzene (T1), 1,2-bis(N’-3–methoxybenzoylthioureido)-4-nitrobenzene (T2) and 1,2-bis(N’-4-methoxybenzoylthioureido)-4-nitrobenzene (T3) have been successfully synthesised. The reaction was performed using 2:1 ratio. The structures of the ligands have been characterised by elemental analysis (CHNS), IR spectroscopy, aH Nuclear Magnetic Resonance (NMR) and melting point determination method. The thiourea ligands were screened for their antibacterial activity using disc diffusion method against Gram-positive bacteria (Bacillus subtillis ATCC 6633, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393) and Gram-negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 10145, and Shigella sonnei ATCC 9290). The efficacy of the compounds against Gram-positive bacteria is higher than Gram–negative bacteria.