Hu Ai-xi
2005
Citations
0
Influential Citations
1
Citations
Journal
Journal of Hunan University
Abstract
4-(2-Hydroxyethyl)-2-(4-methoxyphenyl)morpholine, 2-(2-fluorophenyl)-4-(2-Hydroxyethyl) -3-methyl-morpholine, 2-(4-benzyloxyphenyl)-3-methyl-4-(2-hydroxyethyl)morpholine, 4-(2-hydroxyethyl)- 2-(6-methoxy-2-naphthyl)-morpholine, 4-(2-hydroxyethyl)-2-(6-methoxy-2-naphthyl)-3-methylmorpholine,(3,4)-dimethyl-2-(6-methoxy-2-naphthyl)-morpholine, 3,5-dimethyl-2-(6-methoxy-2-naphthyl)morpholine and 3,5,5-trimethyl-2-(6-methoxy-2-naphthyl)morpholine were synthesized via the reactions of α-bromo-4-methoxyacetophenone, α-bromo-2-fluoropropiophenone, α-bromo-4-benzyloxypropiophenone, 6-methoxy-2-(2-bromoacetyl)naphthalene, 6-methoxy-2-(2-bromopropionyl)naphthalene with diethanolamine, 2-amino-1- propanol, N-methyl-ethanolamine, 2-methyl-2- amino-1-propanol , respectively, in a non-protonic polar solvent at 50 ℃ for 1 h with stirring. Then the mixture was reduced by formic acid at 180 ℃ reflux for 10 h. The 2-arylmorpholines were reacted with hydrochloride to give the hydrochloride salt with yield of 15.6%~58.9%. The structures of the hydrochloride salts of 2-aryl-morpholines were characterized by ()~1H NMR, ()~1H-()~1H COSY, IR and MS spectra.