Zhang Wen-ting
2013
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Journal
Journal of Shaoyang University
Abstract
In the presence of PdCl2/CuCl2/Cy2NH2Cl,a variety of 2-alkynyl benzyl azides smoothly underwent the electronic cyclization to afford the corresponding 3-substituted 4-chloroisoquinolines in 38%~84% yields.The structures were confirmed by 1H NMR,13C NMR and GC-MS.This method had many merits such as simple operation and mild reaction condition.Importantly,a halide was introduced into the products which makes the methodology more attractive for organic synthesis.