He Quan-guo
2007
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Journal
Fine Chemical Intermediates
Abstract
4-Tert-butylphenylboronic acid was synthesized with trimethyl borate and Grignard reagents which was prepared with 1-bromo-4-tert-butylbenzene and metal magnesium as raw materials under N2. An optimized process was obtained as follows: 1.5∶1molar ratio of 1-bromo-4-tert-butylbenzene to trimethyl borate,the temperature -20~-30℃,and the reaction time 140min. The final yield was 69.5%. The product was identified by mass spectrum and HNMR?