Liu Dong-hua
2005
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Maleimido caproic acid, a new potential space arm in modification of protein and peptide drugs, was synthesized by the reaction of 6-aminocaproic acid and maleic anhydride at room temperature in 5.0 h by using acetic anhydride and sodium acetate as a catalyst, and the yield reached 90.34%. The structure was characterized by 1H NMR, IR and LC-MS.