R. Nunna, D. Ramachandran, S. P. Arts
2014
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Abstract
Amino-N-(4-(4-chloro-phenyl)-6-(3,4-dimethyl-phenyl)-pyrimidin-2-yl)-benzensulfonamide (2) was prepared by the hydrolysis of N-{4-(4-Chloro-phenyl}-6-(3,4-dimethyl-phenyl)-pyrimidin-2- ylsulfamoyl)-phenyl}-acetamide (1). It was on-facile condensation reaction with various aromatic aldehydes yields Schiff bases /anils/azomethines (3a-h). These anils on reaction with maleic anhydride and succinic anhydride yield 2H-pyrrole-2-ones (4a-h) and 2-pyrrolidinones (5a-h) respectively. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.