Xinhua Liu, B. Song, Zhu Hailiang
Mar 1, 2008
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0
Influential Citations
10
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Journal
Chinese Journal of Chemistry
Abstract
Ten new 1-(5-(2-chlorophenyl)-3-(2,4-dichlorophenyl)-4,5-dihydropyrazol-1-yl) oxime ester derivatives were synthesized and characterized by elemental analysis, HRMS and 1H NMR data. All the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results show that 7c and 7f possess significant activity with the minimum inhibitory concentrations (MIC) value of 1.562 µg/mL against all the four bacteria. Compounds 7c, 7d and 7f show moderate inhibition against the DNA gyrase (IC50=1.6–2.5 µg/mL). On the basis of the biological result, the structure-activity relationship was discussed.