S. Elsayed, I. Butler, D. Gilson
Jul 8, 2014
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Journal
Journal of Coordination Chemistry
Abstract
Synthesis and characterization of new complexes of 6-methylpyridine-2-carbaldehydethiosemicarbazone (Hmpytsc) and 6-methylpyridine-2-carbaldehyde-N(4)-phenylthiosemicarbazone (Hmpyptsc) with [VO2L], [Zn(HL)Cl2], [Ru(PPh3)2L2], and [MLCl] (M(II) = Pd, Pt; HL = Hmpytsc, Hmpyptsc) are reported. Their structures are discussed on the basis of IR, Raman, UV–vis, NMR (1H, 13C, and 31P), and mass spectroscopic data, as well as elemental analysis and molar conductivity. In the X-ray crystal structure of the square-planar [Pd(mpyptsc)Cl]·DMSO, mpyptsc− is coordinated to Pd(II) in a tridentate manner through pyridyl N, azomethine N, and thiol S, and the fourth coordination site is occupied by a chloride. A theoretical study on [Pd(mpyptsc)Cl]·DMSO was undertaken through DFT conformational analysis. The in vitro cytotoxic activity has been evaluated against human colon cancer (HCT116) and prostate cancer (DU145) cell lines. Hmpyptsc and [Zn(Hmpyptsc)Cl2] were most active with mean IC50 values of 3.32 and 2.60 (HCT116), and 3.60 and 3.10 (DU145) μM, respectively. Graphical Abstract New complexes of 6-methylpyridine-2-carbaldehydethiosemicarbazone (Hmpytsc) and 6-methylpyridine-2-carbaldehyde-N(4)-phenylthiosemicarbazone (Hmpyptsc) and crystal structure of [Pd(mpyptsc)Cl]·DMSO are reported. Hmpyptsc and its complexes were tested against human colon cancer (HCT116) and prostate cancer (DU145) cell lines.