H. Al-Ebaisat, Taher Sharif Ababne, Tareq M. A. Al Shboul
Sep 5, 2016
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
The Journal of Pure and Applied Chemistry Research
Abstract
A series of 4-thiazolidinone derivatives was prepared including 2- (4-phenyl)-3-(4-hydroxyphenyl)thiazolidinone-4-one ( 1 ), 2-(4-bromophenyl)-3-(4-hydroxy phenyl) thiazolidinone-4-one ( 2 ), 2-(4-chlorophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one ( 3 ), 2-(4-methylphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one ( 4 ), 2-(4-metoxyphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one ( 5 ), 2-(4-nitrophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one ( 6 ), 2,3-bis(4-hydroxyphenyl) thiazolidinone-4-one ( 7 ) and 2-(4-ethyl phenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one ( 8 ). The chemical structures of prepared compounds have been characterized by Mass, IR, 1 H-NMR, and elemental analyses. The biological activity of these compounds as fungicides was tested against three commercially known fungicides ( C. albicans , patient isolate C. glabrata and C. krusei ). The biological activity of compound ( 6 ) was found to be comparable to that of the commercially available fungicides.