B. Abbavaram, H. Reddyvari
Dec 20, 2013
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Journal
Journal of The Korean Chemical Society
Abstract
A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine- 1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide deriv- atives 5an. The configurations of these compounds were established by elemental analysis, IR, 1 H NMR, mass spectra, and by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds dem- onstrate significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.