M. Arora, J. Saravanan, S. Mohan
Nov 28, 2012
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Journal
Asian Journal of Research in Chemistry
Abstract
2-Amino-4-(4-acetamido phenyl) Thiophene-3carboxamide was synthesized using versatile Gewald reaction.First step is preparation of cyanoacetamide which was carried out by condensation of ammonia (25%) and ethyl cyano acetate which was then reacted with p-acetanilido acetophenone, sulphur, diethyl amine to give 2-Amino-4-(4-acetamido phenyl) thiophene-3carboxamide.Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 1a-1l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.