N. Rameshbabu, Dr.Sheetal Gulati, Dr.H.S. Patel
Jan 30, 2019
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IARJSET
Abstract
4-Amino-1,2,4-traizol (I) on condensation with 5-Phenyl substituted-2furan carboxaldehyde (IIa-e) yield schiff bases namely N-[(5-Arylfuran-2-yl)methylen]-4H-1,2,4-triazol-4-amine (IIIa-e). Each of schiff base on cyclization with Thioglycolic acid afforded 2-(5-Arylfuran-2-yl)-3-(4H-1,2,4-triazol-4-yl) thiazolidin-4-one (IVa-e). Following this mannich base reaction of each IVa-e with Formaldehyde and Piperidine give 2-(5-Arylfuran-2-yl)-5(piperidin-1-yl methyl)-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (Va-e). All the compounds of each series were characterized by spectral features and elemental contents. The compounds were also screened for their antimicrobial behavior.